Alzheimer’s disease (AD) is the most common cause of dementia among older adults, and current AD therapies provide only symptomatic relief.

Antioxidants like resveratrol (1) and vitamin E (2) have been reported to produce significant neuroprotective effects, but their intrinsic instability precludes any relevant, long-lasting form of therapy.

The potent and selective effect of LGA-1623 against lipid peroxidation, together with its excellent metabolic stability, represents a new “clinically validated” strategy to treat AD patients by preventing its worsening.

(3) Selkoe DJ and Hardy J, EMBO Mol Med 2016; 8: 595–608
(4) Liu et al.,

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